On Wednesday, NIH announced 12 recipients of grants to support research on incorporating DNA sequence information into electronic health records, FierceEMR reports.
The grants have been awarded as part of the third stage of the Electronic Medical Record and Genomics program. The program’s research aims to understand the genomic base of disease and design medical care to meet patients’ individual needs, as determined by their genomic differences (Durben Hirsch, Fierce EMR, 9/2).
With the latest round of grants, researchers are seeking to boost the clinical application of genomics research by identifying potential medical effects of rare genomic variants in about 100 clinically relevant genes (Walsh, Clinical Innovation & Technology , 9/2).
The grants will be administered by the National Human Genome Research Institute (FierceEMR, 9/2).
So far, two groups have received funding:
- About $8.5 million has been awarded to a group at Brigham and Women’s Hospital; and
- About $8.4 million has been awarded to Baylor College of Medicine.
Pending available funding, researchers at:
- Brigham and Women’s Hospital will receive about $3.8 million to determine whether rare and common traits in protein-coding regions of genomes are associated with cardiovascular, neuropsychiatric and immune-related conditions detailed in EHRs;
- Children’s Hospital of Philadelphia will receive about $3.6 million to gain a greater understanding of genetic causes of attention hyperactivity disorder, autism, epilepsy, intellectual disability and obesity, as well as investigate implications for patient care;
- Cincinnati Children’s Hospital will receive about $3.4 million to evaluate the role of genes in the genomes of patients who agree to receive their test results, which investigators will use to find causes of diseases included in EHRs;
- Columbia University will receive about $3.4 million to study a large multi-ethnic population to determine and study genes and genetic variants that add to increase risk of autoimmune disease, birth defects, breast cancer, chronic kidney disease, heart failure, liver disease, neurodevelopmental disorders and stroke;
- Geisinger Health System will receive about $3.5 million to combine EHR information about hypercholesterolemia and chronic rhinosinusitis, as well as examine and test approaches to discussing familiar hypercholesterolemia genomic sequencing results with patients and families;
- Group Health Research Institute/University of Washington, Seattle, will receive about $3.4 million to study preventable diseases and conditions, such as inherited forms of colorectal cancer, high triglycerides and high neutrophil count;
- Mayo Clinic will receive about $3.4 million to explore the underlying genetics of familiar colorectal cancer and familiar hypercholesterolemia as well as examine economic, behavioral and psychological effects of sharing with patients information about which genomic variants are most likely to contribute to these disorders;
- Northwestern University will receive about $3.3 million to determine associations between rare variants in genes collected in earlier studies and share information that could be medically useful to patients and physicians to determine its use and effect on individual patient care;
- Vanderbilt University School of Medicine will receive about $3.4 million for research efforts relating to genomic information and human health and drug responses; and
- Vanderbilt University School of Medicine — under another principal investigator — will receive about $4.2 million to create a coordinating center for data-sharing and genomic quality control (NIH release, 9/2).